54 research outputs found

    Moisture monitoring in clay embankments using electrical resistivity tomography

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    Systems and methods are described for monitoring temporal and spatial moisture content changes in clay embankments using electrical resistivity tomography (ERT) imaging. The methodology is based upon development of a robust relationship between fill resistivity and moisture content and its use in the transformation of resistivity image differences in terms of relative moisture content changes. Moisture level and moisture content movement applications are exemplified using two case histories from the UK. The first is the BIONICS embankment, near Newcastle (NE England), which was constructed in 2005 using varying degrees of compaction of a medium plasticity sandy, silty clay derived from the Durham Till. The second is a Victorian embankment south of Nottingham (Central England), constructed in 1897 using end tipping of Late Triassic siltstone and mudstone taken from local cuttings. Climate change forecasts for the UK suggest that transportation earthworks will be subjected to more sustained, higher temperatures and increased intensity of rainfall. Within the context of preventative geotechnical asset maintenance, ERT imaging can provide a monitoring framework to manage moisture movement and identify failure trigger conditions within embankments, thus supporting on demand inspection scheduling and low cost early interventions

    Aggression, anxiety and vocalizations in animals: GABA A and 5-HT anxiolytics

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    A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. Experimental protocols for the preclinical study of anxiolytic drugs typically involve the suppression of conditioned or unconditioned social and exploratory behavior (e.g., punished drinking or social interactions) and demonstrate the reversal of this behavioral suppression by drugs acting on the benzodiazepine-GABA A complex. Less frequently, aversive events engender increases in conditioned or unconditioned behavior that are reversed by anxiolytic drugs (e.g., fear-potentiated startle). More recently, putative anxiolytics which target 5-HT receptor subtypes produced effects in these traditional protocols that often are not systematic and robust. We propose ethological studies of vocal expressions in rodents and primates during social confrontations, separation from social companions, or exposure to aversive environmental events as promising sources of information on the affective features of behavior. This approach focusses on vocal and other display behavior with clear functional validity and homology. Drugs with anxiolytic effects that act on the benzodiazepine-GABA A receptor complex and on 5-HT 1A receptors systematically and potently alter specific vocalizations in rodents and primates in a pharmacologically reversible manner; the specificity of these effects on vocalizations is evident due to the effectiveness of low doses that do not compromise other physiological and behavioral processes. Antagonists at the benzodiazepine receptor reverse the effects of full agonists on vocalizations, particularly when these occur in threatening, startling and distressing contexts. With the development of antagonists at 5-HT receptor subtypes, it can be anticipated that similar receptor-specificity can be established for the effects of 5-HT anxiolytics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46351/1/213_2005_Article_BF02245590.pd
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